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--- prelude_x [2024/10/14 21:02] – [About] mbates
+++ prelude_x [2024/11/25 21:08] (current) – mbates
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-====== SYMPHONY X ======
+====== Prelude X ======
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 The Prelude X system (Gyros Protein Technologies) enables users to synthesize novel peptides and related structures (peptoids and other solid-phase synthesized sequence specific materials) not available for commercial purchase, providing a lower cost solution for producing peptides with non-natural amino-acids, and supporting the synthesis of branching or cyclic peptides.
-This flexible peptide synthesizer supports various peptide and peptidomimetic chemistries and facilitates multi-user accessibility via 6 fully independent, simultaneous reaction stations with real-time UV monitoring, heating, and vortex mixing on a scale of 10 mg to 2 g of resin per reaction vessel in 10- or 40-mL capacities.
+This peptide synthesizer supports various peptide and peptidomimetic chemistries and facilitates multi-user accessibility via 6 simultaneous reaction stations with real-time UV monitoring, heating, and vortex mixing on a scale of 10 mg to 2 g of resin per reaction vessel in 10- or 40-mL capacities.
-The Prelude X is capable of starting, pausing and stopping reactions vessel (RV) pairs independently of the other RVs on the instrument. Agitation of the reaction is performed by nitrogen bubbling, oscillation mixing, or a combination of these. The system supports Fmoc, t-Boc, organic, peptoid, combinatorial, branched, and PNA chemistries.
+Agitation of the reaction is performed by nitrogen bubbling, oscillation mixing, or a combination of these. The system supports Fmoc, t-Boc, peptoid, and PNA chemistries.
-The system is capable of heating all RVs to 90ºC using induction heating while oscillation mixing the reactor. Elevated temperature can raise reaction rates, accelerating difficult deprotections and couplings that would otherwise cause deletion sequences. Heating can improve the purity of hydrophobic and aggregated sequences.
+The system is capable of heating all RVs to 90 ºC using induction heating while oscillation mixing the reactor. Elevated temperature can raise reaction rates, accelerating difficult deprotections and couplings that would otherwise cause deletion sequences. Heating can improve the purity of hydrophobic and aggregated sequences.
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 • To minimize exposure, perform all operations in a fume hood or ventilated cabinet, including opening reagent bottles, weighing, and transferring reagents. Dispose of contaminated materials in the labeled waste containers, and rinse glassware and tools in the fume hood into designated waste containers.
+• Reagent bottles remain pressurized while the system is operating. Blast shields are in place to protect personnel during use. These shields should only be removed briefly when installing, removing, or refilling reagent bottles, and must be repositioned immediately afterward.
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 ===== Reference Documentation =====
-Coming soon.
+{{ :prelude_x_user_manual.pdf |Prelude X User Manual}}
+{{ :aapptec_synthesis_guide.pdf | Aapptec Peptide Synthesis Guide}}
+{{ :submonomer_synthesis.pdf | Protocols for the Synthesis of Peptoids}}
+[[https://www.peptide.com/resources/solid-phase-peptide-synthesis/cleavage-cocktails/ |Aapptec Cleavage Cocktails]]
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